Prof. Howard Lee was invited to Arirang TV New Show in the morning of April 7, 2023, which is World Health Day set by WHO or the World Health Organization. Prof. Lee talked about the implication of the day, coupled with the accomplishments by WHO, particularly for the last couple of years such as the global management of infectious diseases including the COVID-19 pandemic. Full details of Prof. Lee's interview can be watched at the following YouTube link. 

Prof. Howard Lee has been recently awarded Mid-Career Research Grant from the National Research Foundation (NRF) of South Korea. The total funding amounted to approximately 300 million Korean won spread across three years of research (from year 2023 to 2025). Prof. Howard Lee and his team at CCADD will focus on improving the generalization performance of natural language processing models in extracting drug safety information from multi-institutional clinical notes. More specifically, the team will analyze the semi-structured clinical notes written in diverse clinical settings and investigate the feasibility of using them, along with multi-task generative models, as a way to improve model generalizability. Furthermore, the study will explore the applicability of state-of-the-art generative language models and their ability to augment text data to accomplishing the study objective.

On February 24^th, CCADD celebrated the graduation of two of its members, Siun Kim and David Seung U Lee. Siun, an applied bioengineering major, started his joint Masters and PhD program in 2018 and studied under Prof. Howard Lee’s guidance. He received his PhD in Medicine for his thesis on applying natural language processing technology to drug safety monitoring. David, a molecular medicine and biopharmaceutical sciences (MMBS) major, joined CCADD in 2021 and has since studied under Prof. Howard Lee. He received his MSc in Medicine for his study on clinical characteristics associated with dulaglutide treatment adherence.

Siun, for all his contribution to CCADD, embarked on a new career as a postdoctoral researcher at Seoul National University Hospital Biomedical Research Institute. There, he will focus on developing AI models for the prediction of hypoglycemia during dialysis and the analysis of nursing notes of kidney surgery recipients. David will continue to study under Prof. Howard as a PhD student starting 2023.

We congratulate on their accomplishment and convey our best wishes at their new start.

Prof. Howard Lee was invited to an online forum organized by the Federation Peruana de Enfermedades Raras or FEPER on February 28, 2023. In his talk, Prof. Lee summarized the current drug lags for orphan drugs in South Korea, followed by the challenges and issues for delayed and less-satisfactory reimbursement of orphan drugs. Prof. Lee concluded his talk by proposing new policies and systems to increase the accessibility of orphan drugs in South Korea. They included:1) reduce drug lags, particularly approval lags by the regulatory agency, by continuously innovating and harmonizing regulation, 2) ensure orphan drugs be reimbursed as soon as possible, and 3) fill the gap between the legal status of orphan drugs and the reimbursement policy for drugs to treat rare diseases.

Jung-Hyun Won was invited to the KOREA AI SUMMIT 2022 (“AI for Good”), where she presented the collaboration research project between CCADD (Siun Kim, Jung-Hyun Won, David Seung U Lee, and Prof. Howard) and Microsoft Research Asia (MSRA) entitled “Revisiting and Reformulating Machine Learning-based Drug Repositioning”, orally and as a poster. The Korea AI Summit 2022, organized by AI Innovation Hub, Microsoft Research, IITP, and Korea University AI Research Institute, aimed to provide a platform for academic leaders from the prominent universities and institutes to share and explore the latest developments and technological trends in AI research.

Jung-Hyun Won stated that the team (i.e., CCADD and MSRA) has pointed out problems in the current task formulation of machine learning-based drug repositioning studies. According to Jung-Hyun Won, the team has found the spurious correlation between data collection pattern of drug characteristics and approved indications of drug. They also found that train-test split based on random sampling led to the overestimation of the performances of existing DR models. Jung-Hyun Won stressed that the team is currently reformulating drug repositioning problem as predicting investigational disease and generating eligibility criteria of clinical trials for a drug-disease pair.

Technology showcase can be watched the following youtube thumbnail.

CCADD had a year-end workshop on December 21st, 2022. This year, Prof. Howard Lee and the members of CCADD were joined by PMATCH (the tech start-up led by Prof. Howard) and Dr. Hyun-Ah Lee (our respected alumnus). The workshop was also delightful because some of Prof. Howard’s part-time students and Yujin (our student intern) were there too.

The first session gave a look back on 2022. Accomplishments—academic and otherwise—were shared and celebrated. Prof. Howard cheered the members for their effort and delivered a message of hope for the coming year. The following sessions laid out some concrete plans and goals for 2023, such as attending conferences domestic and abroad and streamlining journal club and book reading programs.

In the afternoon, PMATCH took us down memory lane about all the footsteps leading up to the development of its app, Battery, and its upcoming global debut at CES^® 2023, one of the world’s biggest tech event. Yoomin Jeon, the Chief Technology Officer of PMATCH, stitched all the key moments into a single narrative, which had been so far shared with CCADD in parts.

Perhaps, one of the most anticipated sessions was Dr. Hyun-Ah Lee’s talk about her career after graduation. She traced back her memory from the time when she was studying under Prof. Howard to where she is today. She admitted her life as a PhD student trying to be on par with the rigor and the expectation of Prof. Howard was never easy but definitely worth pursuing. More importantly, she urged us to hang in there as it will all pay off one day, and her sincerity resonated with all of us.

The day’s workshop closed with a special lecture by Prof. Howard. He proposed a vision for CCADD in 2023, exhorting us to recognize the need for honing the necessary skillsets and realigning our research area. Most importantly, Prof. Howard’s closing remark that CCADD should make a bigger leap forward in 2023 taking risks and facing challenges inspired us like nothing else.

Yesol Hong won the Excellent Research Award at the 30th Annual Conference of the Korean Society for Clinical Pharmacology & Therapeutics (KSCPT), December 1-3, 2022, held at Bexco, Busan, South Korea. The title of YeSol's presentation was "One-year follow-up of patients with COVID-19: Analysis of new-onset disease after COVID-19 diagnosis using Real-World Data". She discussed the results of an analysis of the occurrence of disease in patients with COVID-19 over a year using two different real-world data sets. One of her analysis results was a nation-wide study, which was significant in that it included the largest number of study subjects among the studies analyzing the post-COVID-19-condition in Korea. Jung Hyun Won equally contributed to this study with Professor Howard Lee serving as the principal investigator.

Additionally, Siun Kim, Yoona Choi, David Seung U Lee also presented their research through poster exhibition at the conference. 

Full presentations can be watched at the following YouTube links: 

YeSol had the honor to deliver oral presentation and won the Excellent Research Award at 2022 fall conference hosted by the Korean Society of Medical Informatics(KOSMI). YeSol has presented her work entitled "Effectiveness and safety of sodium-glucose cotransporter-2 inhibitors(SGLT2i) added to mono, dual or triple treatment in patients with type 2 diabetes mellitus(T2DM)". She discussed the additive efficacy in glycemic control and the tolerability of SGLT2i in T2DM patients when combined with other antihyperglycemic agents, such as metformin, sulfonylureas, and dipeptidyl peptidase-4 inhibitors using real-world data. Yoona Choi, TaeKyu Chung, and Yoomin Jeon also contributed to this study as co-researchers, with Professor Howard Lee serving as the principle investigator.

The conference was a three-day event (from Nov 23rd, 2022 to Nov 25th, 2022) and was held at The International Convention Center, Jeonbuk National University, Jeonju, Jeonbuk, South Korea. This conference, the host(KOSMI) organized the event around the theme, "The Power and Value of Healthcare Data Linkage". The conference was full of enlightening speeches that reflected the progress made in the field of medical informatics. With a total of 1,039 participants, this conference was held on the largest scale ever among KOSMI conferences. 

Prof. Lee emphasized the nationwide control tower for new drug development in Korea, preferably at the Prime Minister's Office level. This remark came out at a forum Prof. Lee was invited as a speaker, sponsored by Chosun Biz, November 10, 2022. "The control tower should be the epicenter for coordinating diverse government-led supports, policies and activities to make new drug development in Korea much faster and more efficient", Prof. Lee said. "The control tower can be also working as an overarching center for training experts and bringing up more talents required for every single area of drug development, no matter how it is small or large", Prof Lee added.   

A full newspaper article reporting Prof. Lee's speech can be found here. 

The book 'There's no such thing as K-Quarantine', written by Prof.Howard Lee, Jung-Hyun Won, YeSol Hong and 13 others, was selected in the liberal arts section of the Sejong Cultural Book Program this year. The Sejong Cultural Book Program is organized by the Publication industry Promotion Agency of Korea. This program aims to promote domestic publishing activities and to build a knowledge-based society by selecting outstanding books among those published throughout the year. Books worth 8 million Korean won will be distributed to public libraries nationwide. In 2022, 550 books were selected from a total of 8,698 candidates. The book There's no such thing as K-quarantine was selected as an excellent book in the field of technology science. 

Prof. Howard Lee discussed the issues of new drug development policies and strategies laid out by the Yoon government at the 6th Policy Symposium of the Professional Graduate Schools at Seoul National University, held on September 28, 2022 at the Graduate School of International Studies. Prof. Lee started his presentation by telling why it is important to talk about new drug development policies right at this moment. According to Prof. Lee, the likelihood that South Korea can become a leading country in drug development is the highest in history, but it has to be strengthened and guided by the government to make it a true reality. Prof. Lee pointed out the policies and strategies as proposed were too much focused on biologics, infectious disease, and digital health, urgently requiring some levels of balance. Prof. Lee further emphasized the importance of having a nationwide control tower to reduce redundant investments and to facilitate faster actions currently involving too many government agencies and ministries. Prof. Lee concluded his presentation by saying, "Even though all the recommendations are implemented, Korea cannot become a leading country in new drug development unless the society as a whole is ready to pay a price for innovations."

Prof. Lee's presentation can be watched by clicking the following YouTube link: