On May 30th, CCADD came together to celebrate Teacher's Day, creating a memorable evening for Prof. Howard, graduate students, and CCADD members. The event was graced by the presence of Dr. Hyun A Lee, Dr. Siun Kim, Dr. Yoona Choi, and Dr. Tae Kyu Chung, whose attendance added warmth and significance to the occasion.

The evening was enchanting, with a delightful dinner setting the stage for meaningful conversations. Attendees shared recent updates, discussed various research topics, and exchanged personal experiences. Both graduates and current students found inspiration and motivation in each other's stories, drawing strength from their shared journeys.

A heartfelt farewell for Dr. Tae Kyu Chung marked a special highlight of the event. As he prepares to start a new chapter as a postdoctoral researcher at the University of California San Francisco (UCSF), Dr. Chung expressed his gratitude and hopes for future research endeavors. CCADD members honored Dr. Chung’s new journey with full hearts, celebrating his achievements and new beginning.

The gathering reaffirmed the strong bonds within CCADD and emphasized the importance of interaction and collaboration between alumni and current members. This event was more than just a meeting; it was a moment of growth, support, and envisioning a shared future. We hope such gatherings will continue, creating lasting and meaningful memories for all CCADD members.

On December 27th, 2023, CCADD held the year-end workshop at Front1, a startup hub at the heart of Seoul, where PMACH is based. This year, Prof. Howard Lee and the members of CCADD were joined by PMATCH and Dr. Siun Kim. The workshop went on in a dynamic atmosphere, welcoming both Prof. Howard’s part-time student and the interns for the upcoming internship program.

After a brief ice-breaking time, the main session started with a recap of the accomplishments of 2023, reflecting on the overall trajectory. Prof. Howard commended CCADD’s continuous growth in both research and publications. As preparation for 2024, the following session outlined a roadmap, encompassing detailed research ideas and plans for conference to attend in 2024.

The spotlight then turned to CCADD interns. Three passionate interns—Tang Chao, Seorin Choi, and Yunha Noh—who will join the 2024 winter internship program introduced themselves through "Who am I" presentations. Following this, Yujin expressed her aspirations for the path ahead as a new CCADD graduate research student. The workshop proceeded with a lecture on the challenges faced by postdoctoral researchers and strategies for maintaining a healthy mindset among graduate students.

Dr. Siun Kim took a special session to share insights into his post-doctoral journey following graduation. Delivering a lecture on the trending topic of "LLMs in medicine and drug development", he provided valuable perspectives and briefly introduced his ongoing research projects. He candidly shared reflections on the first-year post doc., emphasizing the professional commitment required in the field of research.

Finally, PMATCH summarized their achievements in 2023 and anticipated the upcoming year's developments. With the successful launch of the 'BATTERY' app and a triumphant debut at CES^® 2023, PMATCH envisions a promising future with new team members. Yoomin Jeon, the Chief Technology Officer of PMATCH, expressed her commitment to meeting user’s needs as a must-have app.

The workshop concluded with a keynote address by Prof. Howard. Introducing new trends in 2024, he emphasized the significance of adjusting our research focus and domain knowledge to take another leap forward. Prof. Howard’s central message highlighted 2024 as a pivotal year for CCADD's rebound and PMATCH's inaugural year of growth. 

Prof. Howard Lee gave a talk at an invited symposium in association with the Annual Conference of the Korean Society of Medical Informatics (KoSMI), held both online and offline on November 29, 2023. The title of his presentation was ‘Performance Increase of the Machine Learning Model to Predict Acute Coronary Syndrome in Patients with Type 2 Diabetes Mellitus by Replacing Binary Variables with Propesnsity Score’. This presentation was a culmination of a research project with the same title supported by the Seokcheon Foundation, 2023, where the current and former CCADD graduate students, namely David Seung U Lee, Jung-Hyun Won, and YeSol Hong collectively contributed by proposing a new novel way to address the falseness of binary feature in the electronic medical records. Prof. Lee's speech was well received by the audience evidenced by 6 follow-up questions! The more detailed methodological aspect of Prof. Lee' talk was presented in an accepted poster led by David Seung U Lee.  

CCADD members attended the Annual Conference of the Korean Society for Clinical Pharmacology and Therapeutics (KSCPT), taking place at Sono Belle, Gyeongju, from November 16th to 17th. In this conference, approximately 300 participants shared their insights and findings in the translational pharmacometrics and new drug development realms. 

Representing CCADD, graduate students Tae Kyu and Yoona have delivered oral presentations on the latest advancements in clinical pharmacology and related scientific disciplines at the Conference.

Tae Kyu's oral presentation, centered around the research entitled "Comparison of Machine Learning and Population Pharmacokinetic Models for Predicting Antiepileptic Drug Concentrations Based on Therapeutic Drug Monitoring Records," acquired substantial attention, particularly from pharmacometricians. During the presentation and subsequent discussions, he shared insights on how the application of machine learning to clinical pharmacology holds the potential to revolutionize drug development, dosage optimization, and personalized medicine. 

Yoona also presented her research topic, entitled "Country Contribution of Investigators to Pivotal Clinical Trials and THeir Primary Publications of New Drugs Approved by the US Food and Drug Administration," emphasizing the need for Korean researchers to take an active leadership role in key clinical trials to secure opportunities to contribute as authors to primary publications. The audience also agreed with her suggestions and provided constructive feedback, e.g., why it is not easy to be the author in the primary publications. After her presentation, she commented that it was a valuable opportunity to gauge the interest of clinical pharmacologists in that subject matter. 

In this conference, Tae Kyu and Yoona were bestowed with the esteemed "Best Presentation Award," marking a significant achievement and recognition for their outstanding presentation skills. Out of around 50 accepted abstracts, only the 7 presentations were deemed worthy of the best presentation title. Tae Kyu and Yoona's work was further celebrated with a cash prize of 100,000 KRW.

After all the programmed sessions were over, attendants eagerly awaited the prize draw. In a moment of drawing for the first gift, Howard emerged as the fortunate recipient. With his jaws on the floor, Howard made his way to claim his prize, a Bluetooth Sony Headphone. The annual conference held by KSCPT was a stage to celebrate the lab's commitment to excellence and an opportunity to showcase our gratitute for the fortune we have experienced.

Hardened by the CCADD internship, they took a big leap from being interns to graduate students at the Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University.

During the internship, they were distilled into their purest passion for research in drug development, and combining cutting-edge technology with drug development was the idea that opened the door for both.

As much as they will align nicely with the rest of the team in terms of research interest, we are also excited that they will add a new of diversity to the already diverse CCADD family.

Again, CCADD congratulates them on having taken the important first step to their goals. CCADD will blow the wind at their backs so that they can sail forth and contribute to the greater good of the team and the SNU community at large.

CCADD congratulates Dr. Kyeong-Ryoon Lee's appointment as Visiting Associate Professor at the Department of Molecular Medicine and Biopharmaceutical Sciences (MMBS). The news of Dr. Kyeong-Ryoon Lee's promotion came out on January 26^th, and his new appointment will take effect on March 1^st, 2021.

Dr. Kyeong-Ryoon Lee received his Ph.D. in Pharmaceutical Science at College of Pharmacy, Seoul National University. His research area includes pharmacokinetics, drug metabolism, transporters, and modeling and simulation. Furthermore, Dr. Lee's expertise in artificial intelligence-based modeling, which can be implemented throughout the preclinical and clinical stages of the drug discovery process, has earned him the current position as a research scientist at Korea Research Institute of Bioscience and Biotechnology (KRIBB). 

Dr. Lee's appointment was actually the renewal of his visiting professorship. Dr. Kyeong-Ryoon Lee first joined CCADD on February 2018 as Adjunct Assistant Professor. Since then, Dr. Lee has contributed to CCADD a lot, being a valuable asset for CCADD, not only in research, but in mentoring graduate students.

Once again, CCADD congratulates Dr. Kyeong-Ryoon Lee on his achievement as he is plotting a new path to explore an untapped terrain. CCADD also hopes that Dr. Lee's promotion boosts synergy between CCADD and him. 

CCADD has successfully assembled an interdisciplinary research team at SNU, interested in the application of AI to the development and optimal use of drugs. Recently, the team has received a small, but important, intramural grant to coordinate a series of forums to stimulate, develop, and nurture new, innovative research ideas in the field, entitled “Artificial intelligence for drug development and its optimal use (PI: Prof. Howard Lee)”. Prof. Young Kee Shin, Prof. Eugene C. Yi, Prof. Park Young Joo (from MMBS), Prof. Bongki Moon (from the Dept. of Computer Science and Engineering), Prof. Jung Mi Oh (from the College of Pharmacy), Prof. Jinwook Choi (from the Interdisciplinary Program in Bioengineering), and graduate students in the research teams will meet regularly starting early June 2020 through mid August.

The intramural grant of 3 million Korean won or $2,500 was awarded by the SNU AI Committee. Through the forum, recent progresses in applying AI and machine learning techniques to drug development and its optimal use will be reviewed. Furthermore, the forum will actively seek novel research topics in the fields, which CCADD hopes to end up leading to new grant applications.