Prof. Kyeong-Ryoon Lee lectured at the 2021 Annual Meeting of the Korean Society for Clinical Pharmacology and Therapeutics, held in Jeju-do, Korea, November 11-13, 2021. The title of his talk was Development of Phyisologically-Based Pharmacokinetic Model for Orally-Administered Fexuprazan in Humans. In the lecture, Prof. Lee introduced the audience step-by-step to the drug development project he led in collaboration with Daewoong Pharmaceutical Co., Ltd., Seoul, Korea, where a PBPK model developed using pre-clinical animal data accurately predicted the PK profiles of fexuprazan, a potassium-competitive acid blocker, in humans. Prof. Lee's presentation was based on a research paper he recently published, and was well-received.

Four CCADD members, that is two professors (Prof's. Howard Lee and Kyeong-Ryoon Lee) and two post-docs (Dr's. Hyun-A Lee and Yoo-Kyung Song), taught at a 5-day Advanced Course for Pharmaceutical Medicine or ACPM, December 7-8, 2019, in Seoul National University Hospital. Since 2007, ACPM has been presented 18 times including this year, and Prof. Howard Lee has served as the Chair for the course since 2017. ACPM has been designed to practically dig into seminal areas indispensable for any scientific and efficient drug development program, such as manufacturing and GMP, pre- or non-clinical toxicology, preclinical and clinical ADME (absorption, distribution, metabolism, and excretion), early and late clinical drug developments. 

For this year, Prof. Kyeong-Ryoon Lee, Dr's. Song and Lee shared their >30 year-experience in drug development ADME with a particular emphasis on preclinical pharmacokinetic assessments (Prof. Kyeong-Ryoon Lee), drug metabolism and transporters (Dr. Song), and physiologically-based pharmacokinetic modeling (Dr. Lee). Additionally, Prof. Howard Lee lectured how to design, plan, and conduct efficient early clinical drug development studies. All of the lectures were well accepted! 

Join us in congratulating Hyun A Lee for her successful graduation with a PhD degree in medical science in August 2019! Dr. Hyun A Lee came to CCADD in 2017, 2 years after she started pursuing a PhD degree under Prof. Howard Lee's supervision in association with the Graduate School of Convergence Science and Technology, Seoul National University. Dr. Lee is the first PhD student who has ever graduated from CCADD. The title of her thesis was "Mechanistic Physiologically based Pharmacokinetic/Pharmacodynamic Models to Evaluate the Mutual Relationship between an Acid Pump Antagonist and Intragastric pH in Humans (Using YH4808, a novel K⁺-competitive acid blocker, as an example)".

Dr. Lee will stay with CCADD at least an additional year as a BK21 Plus postdoctoral researcher. She will be performing research in the areas of physiologically-based pharmacokinetic modeling, pharmacokinetic/pharmacodynamics (PK/PD) modeling and simulation, and artificial intelligence-based PK/PD modeling and simulation in clinical drug development.