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    [PUBLICATIONS]

    Kim TE, Lee H, Lim KS, Lee S, Yoon SH, Park KM, Han H, Shin SG, Jang IJ, Yu KS, Cho JY. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014;78(3):556-564.

    [PUBLICATIONS]

    Kim A, Chung I, Yoon SH, Yu KS, Lim KS, Cho JY, Lee H, Jang IJ, Chung JY. Effects of proton pump inhibitors on metformin pharmacokinetics and pharmacodynamics. Drug Metab Dispos. 2014;42(7):1174-1179.

    [PUBLICATIONS]

    Shin D, Cho YM, Lee S, Lim KS, Kim JA, Ahn JY, Cho JY, Lee H, Jang IJ, Yu KS. Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects. Clin Drug Investig. 2014;34(6):383-393.

    [PUBLICATIONS]

    Oh J, Shin D, Lim KS, Lee S, Jung KH, Chu K, Hong KS, Shin KH, Cho JY, Yoon SH, Ji SC, Yu KS, Lee H, Jang IJ. Aspirin decreases systemic exposure to clopidogrel through modulation of p-glycoprotein but does not alter its antithrombotic activity. Clin Pharmacol Ther. 2014;95(6):608-616.

    [PUBLICATIONS]

    Shin KH, Lim KS, Lee H, Jang IJ, Yu KS. An assessment of the pharmacokinetics, pharmacodynamics, and tolerability of GCPGC, a novel pegylated granulocyte colony-stimulating factor (G-CSF), in healthy subjects. Invest New Drugs. 2014;32(4):636-643.

    [PUBLICATIONS]

    Yoon S, Lee H, Kim TE, et al. Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers. Drug design, development and therapy. 2014;8:123-128.

    [PUBLICATIONS]

    Lee H. Is Extrapolation of the Safety and Efficacy Data in One Indication to Another Appropriate for Biosimilars? AAPS J. 2014;16(1):22-26, Epub 11 Oct 2013 DOI: 10.1208/s12248-013-9534-y

    [PUBLICATIONS]

    Chaturvedula A, Sale ME, Lee H. Genetic algorithm guided population pharmacokinetic model development for simvastatin, concurrently or non-concurrently co-administered with amlodipine. Journal of Clinical Pharmacology. 2014;54(2):141-149, Epub 21 SEP 2013 DOI: 10.1002/jcph.176

    [PUBLICATIONS]

    Kim DW, Gu N, Lee H, Jang IJ, Chu K, Yu KS, et al. Usefulness of oral loading of oxcarbazepine suspension in selected patients with epilepsy. Int J Clin Pharmacol Ther. 2013 Oct;51(10):780-6. doi: 10.5414/CP201896.

    [PUBLICATIONS]

    Cha Y-J, Lee H, Gu N, Kim T-E, Lim KS, Yoon SH, Chung J-Y, Jang I-J, Shin S-G, Yu K-S, Cho J-Y. Sustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Participants. Basic Clin Pharmacol Toxicol. 2013;113(6):419-424.

    [PUBLICATIONS]

    Lee H, Jang I-J, Yu K-S, Choi J, Oh B-H. A Population Pharmacokinetic Analysis of Fimasartan, a Selective Angiotensin II Receptor Antagonist, in Healthy Caucasian Subjects and Korean Patients With Hypertension. Clinical Pharmacology in Drug Development. 2013;2(2):162-72. doi: 10.1002/cpdd.10.

    [PUBLICATIONS]

    Lee H, Kim KS, Chae SC, Jeong MH, Kim DS, Oh BH. Ambulatory Blood Pressure Response to Once-Daily Fimasartan: An 8-Week, Multicenter, Randomized, Double-Blind, Active-Comparator, Parallel-Group Study in Korean Patients With Mild To Moderate Essential Hypertension. Clin Ther. 2013;35(9):1337-49. doi: 10.1016/j.clinthera.2013.06.021.

    CCADD

    Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University

    Room C-208, 145 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16229, SOUTH KOREA (Gwanggyo)

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    Tel: +82-31-888-9189 (Gwanggyo); +82-2-3668-7381 (Yeon-gun)

    Fax: +82-31-888-9575

    Email: ccadd.snu@gmail.com