On Friday, December 27, 2024, the 2024 CCADD Year-End Workshop was successfully held at the Seoul National University (SNU) Yongon Campus. The event was attended by Prof. Howard Lee, CCADD members, interns, and alumni. Notably, Research Professor Yoona Choi joined the event in person, while Prof. Asa Johansson and Dr. Tae Kyu Chung participated online, adding an international dimension to the program.

The workshop began with a brief icebreaking session, followed by a series of meaningful presentations. The first presenter, Yunjin Choi, shared her growth and learning experiences over the past six months in her presentation titled “The Serendipitous Road: Lessons from the Past 6 Months.” Next, Yujin Kim reflected on her first year as a graduate student, highlighting her research projects, achievements, and key takeaways. In the afternoon session, Junghyun Won provided a retrospective on her 4.5 years as a graduate student, offering valuable insights into the diverse experiences of graduate life.

The main session reviewed CCADD's accomplishments in 2024, celebrating the research group's growth and achievements. Prof. Howard Lee commended the group’s continued success in research and publications. The workshop then shifted its focus to 2025, with a session outlining a roadmap emphasizing emerging AI concepts and innovative research ideas aligned with the latest trends.

Three special lectures added depth and inspiration to the workshop. Dr. Tae Kyu Chung, a postdoctoral researcher at the University of California San Francisco, delivered a lecture titled “Postdoc Diaries: A Glimpse of Life in the US,” offering a vivid account of his life and research abroad, which resonated strongly with the audience. Research Professor Yoona Choi reflected on her year as a research professor at Child Cancer and Rare Disease Project, Seoul National University Hospital. Her presentation detailed the challenges and achievements of her rigorous research journey, offering valuable insights for fellow researchers. Prof. Asa Johansson from Uppsala University delivered a lecture titled “Pharmacoepidemiology in the Era of Precision Health,” introducing the latest developments in precision medicine and pharmacoepidemiology. Her session provided an opportunity for attendees to exchange ideas with an international expert.

The workshop concluded with an inspiring speech by Prof. Howard Lee, who has been serving as the Dean of the Graduate School of Convergence Science and Technology at SNU. Prof. Lee praised CCADD's remarkable achievements throughout 2024 and expressed his strong support for the group’s ambitious goals in 2025. The 2024 CCADD Year-End Workshop provided members and alumni with a valuable opportunity to strengthen their relationships, exchange ideas, and align on a shared vision for the journey ahead.

Yoona Choi and Jung-Hyun Won attended the 65th Annual Meeting & Exposition of the American Society of Hematology (ASH), which took place from December 9 to 12, 2023, in San Diego, USA. Annually, the ASH conference brings together healthcare professionals, researchers, clinicians, and academics from around the globe to explore advancements in hematology. This prestigious event not only focuses on the study, diagnosis, treatment, and prevention of blood disorders but also features a variety of social events and opportunities for collaboration and the sharing of insights among experts in the field. Official photos from ASH are available here.

At the 'Outcomes Research—Lymphoid Malignancies: Poster II' session, Yoona Choi, serving as the first author and representing the entire research team, presented a study titled 'Evaluating the Effectiveness and Safety of Prephase Steroid Treatment before Remission Induction Chemotherapy in Pediatric Acute Lymphoblastic Leukemia: A Common Data Model-Based Real-World Data Approach.' This study investigated steroid pretreatment in pediatric acute lymphoblastic leukemia (ALL) patients undergoing remission induction chemotherapy (RIC), with the aim of reducing complications such as tumor lysis syndrome (TLS). Analyzing data from Seoul National University Hospital and Catholic University Seoul St. Mary’s Hospital, the study compared patients who received steroid pretreatment at least seven days before RIC with those who did not. The findings indicated a significant reduction in TLS incidence in the pretreated group. While overall survival rates were higher in this group, the difference was not statistically significant. These results provide important real-world evidence for the effectiveness of steroid pretreatment in reducing TLS risk in pediatric ALL patients.

This study was part of a larger project, funded by a grant from the Ministry of Health and Welfare, aiming to develop a disease registry database for pediatric ALL using real-world data in the clinical data warehouse (CDW) of Seoul National University Hospital and Catholic University Seoul St. Mary’s Hospital, thereby generating real-world evidence for pediatric ALL. 

Prof. Lee and David Seung U Lee met with Prof. M. Madan Babu, PhD, FRS, FMedSci, from St. Jude Children's Research Hospital, Memphis, TN, USA, July 17, 2023 in the Grand Hyatt Incheon. Prof. Babu is currently the Endowed Chair in Biomedical Data Science and Director of the Center of Excellence for Data Driven Discovery, St. Jude Children's Research Hospital. He will soon serve as a Senior Vice President and Chief Data Scientist at St. Jude Children's Research Hospital. Prof. Babu is an acclaimed researcher and scientist in various fields including GPCR signaling, regulation and pharmacology, gene , gene regulation, computational biology, structural bioinformatics, and drug discovery. He published many research articles in high-impact journals such as Nature, Science, and Cell. He is also Chief Editor for Molecular Systems Biology journal. 

It has turned out that Prof. Babu had followed the work from CCADD and is interested to know more about what is currently happening in those research areas. In this regard, the main purpose of Prof. Babu's visit this time was to establish professional relationships and set up international scientific bridges with St. Jude to enrich biomedical data science collaborations. Prof. Lee and David detailed the big data science and AI in drug development and optimal usage projects by CCADD, in which Prof. Babu showed great interest. Prof. Babu asked Prof. Lee for additional information and s for those research projects, which David will soon follow up. 

Out of a 3-hour lunch meeting with Prof. Babu, many collaboration opportunities and projects were discussed and proposed, one of which was an exchange program between the two institutions. Co-publication was also talked about, and Prof. Babu asked if CCADD could write a perspective paper regarding drug repurposing using AI for the Molecular Systems Biology journal. Prof. Lee and David hope to see more details soon and will keep CCADD informed. 

 In a gathering of brilliant minds from around the world, Professor Howard and his team attended Conference on Health, Inference, and Learning (CHIL) 2023. The three-day event, held from June 22nd to 24th in Cambridge, Massachusetts, provided a platform for cutting-edge research and discussions on the intersection of artificial intelligence (AI) and healthcare.

Prof. Howard, along with his students Jung Hyun and David, as well as his former student, Siun, were among the select few from South Korea to be invited to this renowned conference. Their attendance was further bolstered by the acceptance of their research paper, titled "Revisiting Machine-Learning Based Drug Repurposing: Drug Indications Are Not a Right Prediction Target," which they presented during the first day's poster session. The team explained the significance and implications of their study, actively engaging with fellow participants and answering questions. More information about the paper can be found here.

The conference encompassed an extensive array of topics, all of which were essential for researchers navigating the rapidly evolving field of AI in healthcare. Attendees were treated to enlightening talks and exciting ideas that spanned innovation, equity, and generalizability in machine learning for health. Discussions included "innovation in machine learning for health," "sharing health data in an age of generative AI: risks, limitations and solutions," "equity implications of machine learning in health: how technology could help or hurt," and "generalizability in machine learning for health: critical for robustness or a distraction from specific validation."

Every moment of the conference proved to be an eye-opening experience. It served as an extraordinary opportunity to broaden their perspectives, push boundaries, and venture beyond their comfort zones.

Yesol Hong won the Excellent Research Award at the 30th Annual Conference of the Korean Society for Clinical Pharmacology & Therapeutics (KSCPT), December 1-3, 2022, held at Bexco, Busan, South Korea. The title of YeSol's presentation was "One-year follow-up of patients with COVID-19: Analysis of new-onset disease after COVID-19 diagnosis using Real-World Data". She discussed the results of an analysis of the occurrence of disease in patients with COVID-19 over a year using two different real-world data sets. One of her analysis results was a nation-wide study, which was significant in that it included the largest number of study subjects among the studies analyzing the post-COVID-19-condition in Korea. Jung Hyun Won equally contributed to this study with Professor Howard Lee serving as the principal investigator.

Additionally, Siun Kim, Yoona Choi, David Seung U Lee also presented their research through poster exhibition at the conference. 

Full presentations can be watched at the following YouTube links: 

The book 'There's no such thing as K-Quarantine', written by Prof.Howard Lee, Jung-Hyun Won, YeSol Hong and 13 others, was selected in the liberal arts section of the Sejong Cultural Book Program this year. The Sejong Cultural Book Program is organized by the Publication industry Promotion Agency of Korea. This program aims to promote domestic publishing activities and to build a knowledge-based society by selecting outstanding books among those published throughout the year. Books worth 8 million Korean won will be distributed to public libraries nationwide. In 2022, 550 books were selected from a total of 8,698 candidates. The book There's no such thing as K-quarantine was selected as an excellent book in the field of technology science. 

Prof. Howard Lee argued that the current dichotomy between 'orphan drugs' and 'treatments for orphan disease' has severely aggravated the lower reimbursement rate by the National Health Insurance Service for orphan drugs, particularly for children. This argument came out from a forum Prof. Lee was invited to at the National Assembly on July 13, 2022. Prof. Lee continued the reimbursement decision for orphan drugs cannot solely be dependent upon cost-effective analysis because the society has to pay ethical and humanitarian attention to children with orphan diseases and their families, not to mention their pains and frustrations. Prof. Lee's plenary talk was well received by the press too, and his full presentation can be watched by clicking the YouTube link below.  

Prof. Lee discussed several ways to increase patient accessibility to advanced biotherapeutics at an online forum on July 9, 2021, sponsored by the National Assembly of the Republic of Korea. The forum was primarily motivated by the recent introduction of innovative advanced biotherapeutics such cell/gene therapy, CAR-T, immunooncology treatment, and antibody-drug conjugate. 

Following the main discussant's overview on the issues, Prof. Lee pointed out that the current health insurance reimbursement system in Korea is not suitable for advanced biotherapeutics, most of which are likely to fail the so-called cost-effectiveness test set and required by the Health Insurance Review and Assessment Service or HIRA because of their astronomical costs. For example, a typical round of treatment with KYMRIAH® or tisagenlecleucel by Novartis will cost a patient ~$500,000 although it is a life-saving drug for patients with rare, but highly fatal form of lymphoma (adults) and leukemia (children). 

Prof. Lee's speech and his follow-up discussion can be watched at YouTube as below. 

Prof. Howard Lee was invited to the 2019 annual congress of the European Association for Clinical Pharmacology and Therapeutics or EACPT2019, held on June 29 - July 2, in Stockholm, Sweden. Prof. Lee gave an overview of the current polypharmacy status in Korea. Polypharmacy, commonly defined as prescribing 6 or more drugs concomitantly on a single prescription, can make patients vulnerable to adverse drug reactions caused by drug interactions. Furthermore, polypharmacy can undermine the financial wellness of the health insurance system. 

In Korea, the proportion of polypharmacy has decreased from 65.8% in early 2000 to 43.7% in 2013. However, polypharmacy is still a big health issue in Korea, particularly in younger children (1-9 years) and the elderly. Likewise, low income is strongly associated with polypharmacy in the elderly in Korea. Currently, there is no national guideline or measure implemented to curb polypharmacy in Korea. Therefore, policies and nationwide efforts, along with educational campaigns for not only patients, but physicians, led by clinical pharmacology professionals, are to be put into practice to keep patients from unwanted health problems caused by polypharmacy and to promote optimal drug therapy. Prof. Lee's talk was well received, followed by an interesting session of discussion at the meeting. A physician in the audience asked why polypharmacy is most common in early childhood in Korea, and Prof. Lee replied, "Prescribing antibiotics and other common cold medications is the major culprit."

The reception for EACPT2019 took place at the Golden Hall, Stockholm City Center. This hall is the place for the ball after the annual Nobel Banquet in the Blue Hall at the City Center. Below are a couple of photos taken at the reception with other Korean participants.