Join us in congratulating David Seung U Lee on his successful graduation with a PhD in Medical Science!

On February 25, David attended the 80th Commencement Ceremony of Seoul National University (SNU), where he received his PhD degree under the supervision of Prof. Howard Lee. He was also awarded with the Best Dissertation Award in recognition of his outstanding research achievements. His dissertation was entitled “Mechanistic Understanding and Prediction of Drug–Drug Interactions in Humans using LLM-Based Multimodal Explainable Framework”.

Dr. Lee is the first PhD graduate of CCADD, who received his degree in the Department of Molecular Medicine and Biopharmaceutical Sciences at the Graduate School of Convergence Science and Technology, Seoul National University. He will continue his academic career at CCADD as a postdoctoral researcher, focusing on clinical natural language processing and artificial intelligence–based drug development.

On February 26th, Professor Howard and the CCADD members gathered to honor the graduation of Tae Kyu Chung and the successful completion of the winter internship program by Seorin Choi and Yunha Noh.

Tae Kyu, who studied the realm of biology-neurobiology as an undergrad, joined CCADD in February 2018 as an intern. Under the guidance of Professor Howard Lee thenceforth, he navigated through the rigors of an integrated master's and PhD program. His persistent dedication to PKPD modeling culminated in a doctoral thesis entitled “Comparison of Machine Learning and Population Pharmacokinetic Models for Predicting Antiepileptic Drug Concentrations Based on Therapeutic Drug Monitoring Records”, earning him a Doctor of Medicine degree. On the graduation day, his relentless pursuit was duly awarded.

Simultaneously, a ceremony to mark the completion of Seorin and Yunha's internship was conducted at the main campus of Seoul National University. Throughout their internship, they immersed themselves in a series of educational endeavors, presentations, and assignments. On that day, their efforts, all contained within a comprehensive poster presentation, were met with a deep appreciation. Members of CCADD also attended the ceremony to celebrate the completion of their internships.

As we congratulate their accomplishments, we also look forward with anticipation to their future as independent researchers.

Yoona Choi and Jung-Hyun Won attended the 65th Annual Meeting & Exposition of the American Society of Hematology (ASH), which took place from December 9 to 12, 2023, in San Diego, USA. Annually, the ASH conference brings together healthcare professionals, researchers, clinicians, and academics from around the globe to explore advancements in hematology. This prestigious event not only focuses on the study, diagnosis, treatment, and prevention of blood disorders but also features a variety of social events and opportunities for collaboration and the sharing of insights among experts in the field. Official photos from ASH are available here.

At the 'Outcomes Research—Lymphoid Malignancies: Poster II' session, Yoona Choi, serving as the first author and representing the entire research team, presented a study titled 'Evaluating the Effectiveness and Safety of Prephase Steroid Treatment before Remission Induction Chemotherapy in Pediatric Acute Lymphoblastic Leukemia: A Common Data Model-Based Real-World Data Approach.' This study investigated steroid pretreatment in pediatric acute lymphoblastic leukemia (ALL) patients undergoing remission induction chemotherapy (RIC), with the aim of reducing complications such as tumor lysis syndrome (TLS). Analyzing data from Seoul National University Hospital and Catholic University Seoul St. Mary’s Hospital, the study compared patients who received steroid pretreatment at least seven days before RIC with those who did not. The findings indicated a significant reduction in TLS incidence in the pretreated group. While overall survival rates were higher in this group, the difference was not statistically significant. These results provide important real-world evidence for the effectiveness of steroid pretreatment in reducing TLS risk in pediatric ALL patients.

This study was part of a larger project, funded by a grant from the Ministry of Health and Welfare, aiming to develop a disease registry database for pediatric ALL using real-world data in the clinical data warehouse (CDW) of Seoul National University Hospital and Catholic University Seoul St. Mary’s Hospital, thereby generating real-world evidence for pediatric ALL. 

Prof. Lee and David Seung U Lee met with Prof. M. Madan Babu, PhD, FRS, FMedSci, from St. Jude Children's Research Hospital, Memphis, TN, USA, July 17, 2023 in the Grand Hyatt Incheon. Prof. Babu is currently the Endowed Chair in Biomedical Data Science and Director of the Center of Excellence for Data Driven Discovery, St. Jude Children's Research Hospital. He will soon serve as a Senior Vice President and Chief Data Scientist at St. Jude Children's Research Hospital. Prof. Babu is an acclaimed researcher and scientist in various fields including GPCR signaling, regulation and pharmacology, gene , gene regulation, computational biology, structural bioinformatics, and drug discovery. He published many research articles in high-impact journals such as Nature, Science, and Cell. He is also Chief Editor for Molecular Systems Biology journal. 

It has turned out that Prof. Babu had followed the work from CCADD and is interested to know more about what is currently happening in those research areas. In this regard, the main purpose of Prof. Babu's visit this time was to establish professional relationships and set up international scientific bridges with St. Jude to enrich biomedical data science collaborations. Prof. Lee and David detailed the big data science and AI in drug development and optimal usage projects by CCADD, in which Prof. Babu showed great interest. Prof. Babu asked Prof. Lee for additional information and s for those research projects, which David will soon follow up. 

Out of a 3-hour lunch meeting with Prof. Babu, many collaboration opportunities and projects were discussed and proposed, one of which was an exchange program between the two institutions. Co-publication was also talked about, and Prof. Babu asked if CCADD could write a perspective paper regarding drug repurposing using AI for the Molecular Systems Biology journal. Prof. Lee and David hope to see more details soon and will keep CCADD informed. 

On February 24th, David was invited to attend the 77^th commencement ceremony of Seoul National University (SNU). The event celebrated a total of 4,637 students (2,154 undergraduates, 1,708 master’s students, and 775 PhD students) who received their degrees. That day, David had the honor to be awarded his degree by President Ryu Hong Lim, representing 41 graduating master’s students of the Graduate School of Convergence Science and Technology, Seoul National University.

On February 24^th, CCADD celebrated the graduation of two of its members, Siun Kim and David Seung U Lee. Siun, an applied bioengineering major, started his joint Masters and PhD program in 2018 and studied under Prof. Howard Lee’s guidance. He received his PhD in Medicine for his thesis on applying natural language processing technology to drug safety monitoring. David, a molecular medicine and biopharmaceutical sciences (MMBS) major, joined CCADD in 2021 and has since studied under Prof. Howard Lee. He received his MSc in Medicine for his study on clinical characteristics associated with dulaglutide treatment adherence.

Siun, for all his contribution to CCADD, embarked on a new career as a postdoctoral researcher at Seoul National University Hospital Biomedical Research Institute. There, he will focus on developing AI models for the prediction of hypoglycemia during dialysis and the analysis of nursing notes of kidney surgery recipients. David will continue to study under Prof. Howard as a PhD student starting 2023.

We congratulate on their accomplishment and convey our best wishes at their new start.

CCADD had a year-end workshop on December 21st, 2022. This year, Prof. Howard Lee and the members of CCADD were joined by PMATCH (the tech start-up led by Prof. Howard) and Dr. Hyun-Ah Lee (our respected alumnus). The workshop was also delightful because some of Prof. Howard’s part-time students and Yujin (our student intern) were there too.

The first session gave a look back on 2022. Accomplishments—academic and otherwise—were shared and celebrated. Prof. Howard cheered the members for their effort and delivered a message of hope for the coming year. The following sessions laid out some concrete plans and goals for 2023, such as attending conferences domestic and abroad and streamlining journal club and book reading programs.

In the afternoon, PMATCH took us down memory lane about all the footsteps leading up to the development of its app, Battery, and its upcoming global debut at CES^® 2023, one of the world’s biggest tech event. Yoomin Jeon, the Chief Technology Officer of PMATCH, stitched all the key moments into a single narrative, which had been so far shared with CCADD in parts.

Perhaps, one of the most anticipated sessions was Dr. Hyun-Ah Lee’s talk about her career after graduation. She traced back her memory from the time when she was studying under Prof. Howard to where she is today. She admitted her life as a PhD student trying to be on par with the rigor and the expectation of Prof. Howard was never easy but definitely worth pursuing. More importantly, she urged us to hang in there as it will all pay off one day, and her sincerity resonated with all of us.

The day’s workshop closed with a special lecture by Prof. Howard. He proposed a vision for CCADD in 2023, exhorting us to recognize the need for honing the necessary skillsets and realigning our research area. Most importantly, Prof. Howard’s closing remark that CCADD should make a bigger leap forward in 2023 taking risks and facing challenges inspired us like nothing else.