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[NEWS]

Prof. Lee spoke at X+AI Workshop 2020

Three months ago, CCADD was awarded an intramural grant to present an AI forum to develop new research ideas, hopefully leading to an extramural grant application, for the efficient use of AI technologies for new drug development. Concluding this interdisciplinary endeavor, Prof. Howard Lee talked at the X+AI Workshop 2020 on August 24, along with 10 other PI's. The AI forum Prof. Lee has led consisted of an interdisciplinary team of seven professors at SNU, and they have met weekly or biweekly a total of 8 times, all virtual due to the Corona pandemic, which is utterly unheard of.

At the Workshop, Prof. Lee summarized what objectives the team has accomplished in various research areas in drug development where AI technologies can be adopted. Furthermore, Prof. Lee emphasized what hurdles needed to be overcome if more AI technologies could be employed to make the current drug developments practices faster, less costly, and more efficient. Prof. Lee's talk was well received, and he was approached by several PIs in other fields after the Workshop, who would like to extend their research network.

CCADD is currently working on an extramural grant application based on the insights gained at the forum. In addition, Prof. Lee's presentation can be watched at YouTube below.

[NEWS]

YeSol Hong, BS, joined CCADD

YeSol Hong joined CCADD as a graduate student at the Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University. She graduated Sookmyung Women’s University in 2010 with a bachelor’s degree in Economics. Before she joined CCADD, she worked at Eli Lilly and Company (2009-2016), Novartis (2016-2018) and AstraZeneca (2018-2020) for 12 years. She is interested in using artificial intelligence and big data for new drug development. By actively participating in various convergence technology research projects at CCADD, YeSol wants to contribute to proposing ways to make drug development process more efficient and less costly.

[PUBLICATIONS]

Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee H, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, Lumpkin MM, Giacomini KM, Blaschke TF. Scientific considerations for global drug development. Science Translational Medicine. 2020. doi:10.1126/scitranslmed.aax2550

[NEWS]

The first commentary from CCADD has been published!

Yoomin Jeon, Yoona Choi, Esther Hehsun Kim, SeonYeong Oh, and Howard Lee have published a commentary, titled "Common data model-based real-world data for practical clinical practice guidelines: clinical pharamacology perspective", in Transnational and Clinical Pharmacology. It's the first commentary CCADD members have ever written.

Through this commentary, the authors overviewed the major shortcomings of the current clinical practice guidelines (CPGs) in 3 common chronic diseases such as type 2 diabetes mellitus, dyslipidemia, and chronic obstructive pulmonary disease. Furthermore, the authors offered new perspectives on the adequate and innovative use of common data model (CDM)-based real-world data (RWD) to complement the existing CPGs.

This was actually based on the authors' work for the previous application to the request for proposal on the development of CDM-based CPGs and treatment algorithm from the Ministry of Trade, Industry and Energy of Korea in last March. Though the authors failed to win the project, despite of their concerted efforts in preparing the proposal for almost a month, they came to realize the strong potential to utilize CDM-based RWD to improve the current randomized controlled trials-based CPGs. The gained collective understanding, knowledge, and insights were successfully welded into the commentary.

CCADD will continue to develop innovative ways to promote CDM for clinical drug development, especially in collaboration with the Observational Health Data Sciences and Informatics (OHDSI) research network using the Observational Medical Outcomes Partnership (OMOP) CDM.

[NEWS]

2020 Summer Internship

Two undergraduate students (Jung-Hyun Won and Minyeong Son) joined CCADD for the 2020 Summer Intership program, and they will spend the next 2 months experiencing the research environment while participating in the active research projects at CCADD.

Jung-Hyun Won is a fourth-year undergraduate student at Chung-Ang University, double majoring in Biotechnology (Animal Science and Technology) and Biomedical Engineering. Previously, Jung-Hyun worked as an intern at GSK Korea, a global pharmaceutical company, where she has developed a broad interest in pharmacology and drug development. During the internship program at CCADD, Jung-Hyun is looking forward to learning drug development processes as well as the basics of clinical pharmacology and artificial intelligence (AI) algorithms applicable to the pharmaceutical area.

Minyeong Son is a third-year undergraduate student at Dongguk University, double majoring in Biomedical Engineering and Convergence Software. Minyeong is interested in AI technologies and their practical applications to drug development to make it more efficient and productive. Minyeong wants to learn how to analyze medical data using computer languages, such as Python and R, which could be accomplished by becoming an active member, though limited, of the various research teams at CCADD.

[NEWS]

CCADD leads an SNU AI forum for efficient development and optimal use of drugs

CCADD has successfully assembled an interdisciplinary research team at SNU, interested in the application of AI to the development and optimal use of drugs. Recently, the team has received a small, but important, intramural grant to coordinate a series of forums to stimulate, develop, and nurture new, innovative research ideas in the field, entitled “Artificial intelligence for drug development and its optimal use (PI: Prof. Howard Lee)”. Prof. Young Kee Shin, Prof. Eugene C. Yi, Prof. Park Young Joo (from MMBS), Prof. Bongki Moon (from the Dept. of Computer Science and Engineering), Prof. Jung Mi Oh (from the College of Pharmacy), Prof. Jinwook Choi (from the Interdisciplinary Program in Bioengineering), and graduate students in the research teams will meet regularly starting early June 2020 through mid August.

The intramural grant of 3 million Korean won or $2,500 was awarded by the SNU AI Committee. Through the forum, recent progresses in applying AI and machine learning techniques to drug development and its optimal use will be reviewed. Furthermore, the forum will actively seek novel research topics in the fields, which CCADD hopes to end up leading to new grant applications.

[PEOPLE]

Chae Jeong Lee

Chae Joeng Lee was a student researcher at the Center for Convergence Approaches in Drug Development (CCADD), Graduate School of Convergence Science and Technology, Seoul National University. Since she joined the Smart Internship Program at CCADD early 2020, Chae Jeong participated in a Small Grant Exploratory Research (SGER) grant project, supported by the National Research Foundation. Chae Jeong was also a full-time student at Hankuk University of Foreign Studies with a major in biomedical engineering and a minor in computer engineering. Using her coding and programming skills, Chae Jeong aimed to identify the common sensitive eligibility features that could increase the efficiency of clinical trial feasibility.

[PEOPLE]

Jinyeong Yang

Jinyeong Yang was a student researcher at the Center for Convergent Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University. Jinyeong is also a third-year undergraduate student at the College of Agriculture and Life Sciences, Seoul National University, where she studies animal biotechnology. Jinyeong joined CCADD through the 2020 Winter Internship program and participated in a research project, supported by the National Research Foundation. In this project, Jinyeong identified the common sensitive eligibility features for clinical trials using machine learning techniques, which would help recruiting eligible patients more efficiently.

[NEWS]

2020 Winter Smart Internship has completed!

Six undergraduate students (Sung Jong Kim, Hwe Won Kim, Jinyeong Yang, Song Yeon Oh, Chae Jeong Lee, and Yura Hwang) have successfully completed the 8 week-long '2020 Winter Smart Internship' with no dropout or leftover. The students have not only learned how to do data science by reviewing two textbooks “R for Data science” and “GGPlot 2, Essential R”, but also participated in several ongoing CCADD research projects awarded by the Ministry of Trade, Industry and Energy, Korea Health Industry Development Institute, and Ministry of Food and Drug Safety. The internship program was an opportunity to garner insights as to how machine learning and data science could address some challenges drug development has long suffered from. Although the internship program was over, four students (Sung Jong Kim, Yura Hwang, Jinyeong Yang, and Chae Jeong Lee) have decided to continue participating in the CCADD projects and lab activities. On the other hand, Song Yeon Oh and Hwe Won Kim are exploring other opportunities. Prof. Howard Lee congratulated the students for their achievements, saying “This year’s winter internship program was quite unique in that CCADD has never had this many students before while four of them would continue involving in the research activities.”

[NEWS]

Yoona Choi, RPh, joined CCADD

Yoona Choi, R. Ph, joined CCADD as a graduate student at the Department of the Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University. Yoona graduated from Pusan National University (2004-2008) with a bachelor’s degree in pharmacy in 2008, and has worked in several global pharmaceutical companies including Pfizer, Astellas, Bayer and AstraZeneca for 12 years, particularly in the field of oncology drug development. Based on her experience of working in the area of precision medicine in oncology, she wants to further study the use of artificial intelligence or big data for clinical drug development at CCADD, hoping that great drugs can reach to the optimal patients earlier.

[PEOPLE]

Yoona Choi, Ph.D, R.Ph.

Yoona Choi, Ph.D., R.Ph, is currently a Research Professor at Child Cancer and Rare Disease Project of Seoul National University Hospital. She was a graduate student at the MS/PhD integrated program of the Department of the Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University. After graduating from Pusan National University (2004-2008) with a bachelor’s degree in pharmacy, she has worked in several global pharmaceutical companies for 12 years, particularly in the field of oncology drug development.

[NEWS]

Seonyeong Oh, an experienced nurse, joined CCADD as a researcher

Seonyeong Oh, RN, joined CCADD as a researcher. Seonyeong studied nursing at Inha University and has 4-year experience as a registered nurse (2014 - 2018) in various clinical settings such as emergency room, intensive care unit, and general hospital ward. Seonyeong has been working on her master’s degree in global health at the Catholic Graduate School of Health. Under Prof. Howard Lee’s supervision, Seonyeong is currently collaborating with other researchers, both inside and outside of CCADD, to develop, revise, and refine machine learning algorithms that will allow for drug development scientists and executives alike for forecasting a realistic number of eligible patients for a planned clinical trial.

Congratulating Seonyeong’s new journey at CCADD, Prof. Lee made it clear that CCADD was entering into a new development. “Seonyeong’s clinical background and expertise as a medical professional will strengthen CCADD in many ways, particularly in the area of data-driven clinical trial research, which is a pleasant and timely thing to watch”, Prof. Lee added.

CCADD

Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University

Room C-208, 145 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16229, SOUTH KOREA (Gwanggyo)
Room 406, Building 17, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, SOUTH KOREA (Yeon-gun)

Tel: +82-31-888-9189 (Gwanggyo); +82-2-3668-7381 (Yeon-gun)

Fax: +82-31-888-9575

Email: ccadd.snu@gmail.com

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Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University

Room C-208, 145 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16229, SOUTH KOREA (Gwanggyo)Room 406, Building 17, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, SOUTH KOREA (Yeon-gun)

Room C-208, 145 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16229, SOUTH KOREA (Gwanggyo)
Room 406, Building 17, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, SOUTH KOREA (Yeon-gun)